Evaluation of COX-2 Expression in Renal Cell Carcinoma and its correlation with clinicopathological factors: A tissue microarray study.

Guheina Abdullah Ashour, Warda M. Said

Abstract

Objectives: this study, aimed to evaluate the expression of COX2 in renal cell carcinoma (RCC), and correlate it with different patient clinicopathological data, emphasizing on the role of COX2 as a prognostic factor for RCC and to decide which cases more likely  benefit from the targeted therapy later on.

Patients and Methods: the present series consisted of tissue samples obtained from 50 patients (30 patients were men and 20 were women). All the tumor samples were collected from the Pathology Department, Faculty of Medicine, Alexandria University during the period from July 2009 to November 2010.  Archival paraffin-embedded RCC tissue samples were used to prepare tissue microarray blocks for immunohistochemical staining with COX2 antibody. Marker expression was categorized for statistical analysis then correlated to clinicopathological variables.

Results: the histological types was significantly associated with COX2 expression, with higher expression being more common in  papillary RCC and chromophobe RCC, the majority of these two types were in score 1 and 2  while majority of  clear cell RCC had  score 0 and 1 (P=0.011*).

Conclusion: The association of COX-2 marker was related to the histologic type of tumor; COX2 expression study might provide prognostic information regarding tumor aggressiveness. These findings suggested a potential impact of COX2 targeted therapy in the treatment of RCC with overexpressed COX2 that needs further investigation.

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